Selecting the second messenger
نویسندگان
چکیده
منابع مشابه
-Second Messenger-
Genetic polymorphisms and environmental factors work with and against each other to affect neurodevelopment and the delicate balance of neurotransmitters that underlie psychiatric disorders. This article explores the complex nature of gene-gene and gene-environment interactions and the implications for diagnosis and treatment of disease. As an example of this dynamic relationship, the gene for ...
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Organisations are called upon to make decisions almost continuously, and one of the most common models for doing so utilises a format with which most are all too familiar — gathering relevant individuals together in a meeting to discuss the issues at hand and reach a decision to be implemented. This approach seems at first glance to be an ideal strategy, but 50 years of research on the drawback...
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Cyclic AMP (adenosine 3',5'-monophosphate or cyclic adenylate) has now been established as a second messenger mediating many of the effects of a variety of hormones. Severial of the metabolic effects mediated by cyclic AMP are discussed, and it is suggested that certain other ("functional" or "mechanical") hormonal effects may be similarly mediated. In particular, the evidence presented support...
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Understanding the effect of neuromodulators requires modeling the dynamics of second messenger pathways and their effects on channel properties. Chemesis is software for modeling enzyme reactions, stoichiometric reactions, diffusion, and ligand gating of channels and is used in conjunction with GENESIS, the software program for neuronal modeling. This chapter explains the differential equations...
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Post-transcriptional regulation of the asialoglyco-protein receptor (ASGR) in the HepG2 cell line can be mediated by the presence of biotin in the culture medium. To determine if the induction by biotin of intracellular cGMP affects ASGR expression, HepG2 were grown in biotin-depleted medium with the cell-permeant 8-bromo-cGMP (8-Br-cGMP). Both cell-surface and total ASGR binding of iodinated a...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2012
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1150